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Desensitization and Reduction of Chronic Pain

The University of Texas at Dallas presents a novel class of inhibitors, specificity-derived competitive inhibitor oligonucleotides (SPOT-ONs) that bind to poly(A) binding protein (PABP), and the associated inventive strategy to treat pathological pain. Pathological pain plasticity has been shown to take place in nociceptors, sensory neurons which...

Published: 4/26/2019 | Inventor(s):

Keywords(s): Chemistry, Diagnostics, Healthcare, Life Sciences, Molecular Biology, Therapeutics

Category(s): Research Tools

Neurocase: Peripheral Nerve Electrode for Neural Recording and Stimulation

The ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response, which can lead to neuron damage and reduced reliability of results. Minimizing such tissue responses is necessary to develop implantable interfaces for studying neural activity and even...

Published: 1/5/2022 | Inventor(s): Stuart Cogan, Atefeh Ghazavi, Alexandra Joshi-Imre

Keywords(s): Biocompatible, Biotechnology, Electronics, Engineering & Physical Sciences, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Devices, Research Tools

Powered Prosthetic Leg for Restoring Natural Locomotion and Mobility Across Tasks

Current passive prostheses are used to alleviate the effects of amputation, but they are limited in their ability to completely restore functionality because such mechanisms may only dissipate energy that the user introduces. In the case of above-knee amputees, many passive prosthetic devices aim to mimic normal walking conditions but typically leave...

Published: 5/20/2020 | Inventor(s): Robert Gregg, Toby Elery, Siavash Rezazadeh, Christopher Nesler

Keywords(s): Devices, Electronics, Energy Storage & Battery, Engineering & Physical Sciences, Healthcare, Life Sciences, Mechanical Systems, Medical, Medical Devices, Therapeutics

Category(s): Robotics

Noninvasive & High-Contrast Imaging of Kidney Function Enabled by Renal Clearable Nanofluorophores

The University of Texas at Dallas is seeking companies interested in commercializing a renal-clearable contrast agent that is the first to enable high-resolution, noninvasive, fluorescent imaging of kidney function. Kidney disease affects more than 10% of adults worldwide and the current technologies used to detect and track the progress of renal complications...

Published: 4/26/2019 | Inventor(s): Jie Zheng, Mengxiao Yu

Keywords(s): Biocompatible, Biomarkers, Chemistry, Diagnostics, Healthcare, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools

Category(s): Biomedical, Imaging

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Synthetic Binders of Breast Cancer Stem Cells

In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a root of tumor recurrence and metastasis. Several known...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Luxi Chen, Chao Long

Keywords(s): Assay, Biomarkers, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Polymers, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Method for Measuring Carbon Nanotubes Taken-Up by a Plurality of Living Cells

Carbon nanomaterials (CNMs), including carbon nanotubes (CNTs) and graphene, are undergoing extensive research due to their diverse commercial applications and potential for biomedical uses. The global increase in the production of CNMs and incorporation into consumer products is cause for concern because of the consistent reports that CNMs can be toxic....

Published: 4/26/2019 | Inventor(s): Rockford Draper, Paul Pantano, Ru-Hung Wang, Carole Mikoryak

Keywords(s): Assay, Biotechnology, Carbon Nanomaterials, Carbon Nanotubes, Engineering & Physical Sciences, Healthcare, Imaging, Life Sciences, Materials, Microfluidics, Molecular Biology, Nanotechnology, Processes

Category(s): Research Tools

Enhancing Plasticity and Recovery Following Spinal Cord Injury

Spinal cord injury (SCI) can lead to a wide range of functional impairments that reduce the independence and quality of life for millions worldwide. Intense rehabilitation therapy is the most consistently effective therapy for SCI patients, but serious impairments may persist even after years of treatment.While the impairments that result from SCI are...

Published: 4/26/2019 | Inventor(s): Robert Rennaker, Michael Kilgard, Seth Hays, Patrick Ganzer

Keywords(s): Electronics, Healthcare, Implantable, Life Sciences, Medical, Medical Devices, Therapeutics

Category(s): Biomedical

Compact System for Label-Free Analysis of Binding Kinetics for Multiple Analytes

There are numerous problems faced with many of the standard biomolecular analysis tools, such as limited sensitivity, expensive set-up and per-test necessities, and space requirements that have prohibited their use outside of a dedicated laboratory space. The need for a portable and inexpensive diagnostic tool that can be customized for various target...

Published: 4/26/2019 | Inventor(s): Shalini Prasad, Anjan Panneer Selvam

Keywords(s): Biocompatible, Biomarkers, Devices, Electronics, Engineering & Physical Sciences, Healthcare, Life Sciences, Medical, Medical Devices, Molecular Biology

Category(s): Diagnostics

Portable Electrochemical Impedance System for Universal Molecular Diagnostics

Current methods of producing molecular diagnostic tools have many drawbacks, such as: the high-cost of fabrication, poor biodegradability, limited customizability, or issues with controlled fluid flow. Such problems have limited the ability to create portable detection devices for use in point-of-care settings that use environmentally-safe disposable...

Published: 4/26/2019 | Inventor(s): Shalini Prasad, Anjan Panneer Selvam

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Devices, Electronics, Engineering & Physical Sciences, Healthcare, Life Sciences, Medical, Medical Devices, Microfluidics, Molecular Biology

Category(s): Diagnostics

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