Search Results - biomarkers

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Multiplexed Chip System for Analysis of Drug Activity in Cell Extracts

This technology uses multielectrode chips with DNA monolayers to analyze drug activity of DNA-damaging cancer treatments to inform therapeutic decisions for personalized medicine. Due to the unpredictability of cancer drugs, it is difficult to identify which therapy will work most effectively for each individual while producing minimal side effects....

Published: 4/26/2019 | Inventor(s): Jason Slinker, Dimithree Kahanda, David Boothman

Keywords(s): Assay, Biomarkers, Cell Lines, Devices, Engineering & Physical Sciences, Materials, Medical, Membrane, Microfluidics, Processes, Therapeutics

Category(s): Electronics, Diagnostics, Healthcare, Research Tools

Transient Optical Opening of the Blood-Brain Barrier by Laser Excitation of Plasmonic Nanoparticles

The blood-brain barrier (BBB) poses a low permeability to most drugs and poses a significant challenge to effective treatment of brain diseases. The BBB restricts the delivery of most drug molecules into the brain by tight junctions (TJs) that seal gaps between adjacent endothelial cells, displaying low permeability and high electrical resistance. Herein,...

Published: 4/26/2019 | Inventor(s): Zhenpeng Qin, Xiaoqing Li, Xiuying Li, Shashank Sirsi, Heather Hayenga, Edward Pan

Keywords(s): Biomarkers, Diagnostics, Drug Delivery, Engineering & Physical Sciences, Imaging, Materials, Medical, Research Tools, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

Novel Aconitase: Targeting Phenotypic Adaptation for Antimicrobial Development

Worldwide, bacterial pathogens pose an alarming public health threat due to their resistance to current antimicrobial drugs. While antibiotics have been widely used to prevent bacterial infections over the last 50-60 years, all major bacterial pathogens now are showing resistance to currently prescribed antibiotics worldwide. Increasing drug resistance...

Published: 4/26/2019 | Inventor(s): Mehmet Candas, Lee Bulla

Keywords(s): Antibiotics, Biomarkers, Life Sciences, Medical, Molecular Biology, Therapeutics

Category(s): Healthcare, Research Tools

Noninvasive & High-Contrast Imaging of Kidney Function Enabled by Renal Clearable Nanofluorophores

The University of Texas at Dallas is seeking companies interested in commercializing a renal-clearable contrast agent that is the first to enable high-resolution, noninvasive, fluorescent imaging of kidney function. Kidney disease affects more than 10% of adults worldwide and the current technologies used to detect and track the progress of renal complications...

Published: 4/26/2019 | Inventor(s): Jie Zheng, Mengxiao Yu

Keywords(s): Biocompatible, Biomarkers, Chemistry, Diagnostics, Healthcare, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools

Category(s): Biomedical, Imaging

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Synthetic Binders of Breast Cancer Stem Cells

In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a root of tumor recurrence and metastasis. Several known...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Luxi Chen, Chao Long

Keywords(s): Assay, Biomarkers, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Polymers, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Compact System for Label-Free Analysis of Binding Kinetics for Multiple Analytes

There are numerous problems faced with many of the standard biomolecular analysis tools, such as limited sensitivity, expensive set-up and per-test necessities, and space requirements that have prohibited their use outside of a dedicated laboratory space. The need for a portable and inexpensive diagnostic tool that can be customized for various target...

Published: 4/26/2019 | Inventor(s): Shalini Prasad, Anjan Panneer Selvam

Keywords(s): Biocompatible, Biomarkers, Devices, Electronics, Engineering & Physical Sciences, Healthcare, Life Sciences, Medical, Medical Devices, Molecular Biology

Category(s): Diagnostics

Portable Electrochemical Impedance System for Universal Molecular Diagnostics

Current methods of producing molecular diagnostic tools have many drawbacks, such as: the high-cost of fabrication, poor biodegradability, limited customizability, or issues with controlled fluid flow. Such problems have limited the ability to create portable detection devices for use in point-of-care settings that use environmentally-safe disposable...

Published: 4/26/2019 | Inventor(s): Shalini Prasad, Anjan Panneer Selvam

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Devices, Electronics, Engineering & Physical Sciences, Healthcare, Life Sciences, Medical, Medical Devices, Microfluidics, Molecular Biology

Category(s): Diagnostics

Novel Class of pH Responsive and Renal Clearable Tumor Imaging Agents

Non-Confidential Description:The technology is a novel class of pH responsive luminescent gold nanoparticles that are renal clearable and that selectively bind to cells in an acidic environment such as tumor cells. An advantage of these novel pH responsive nanoparticles is that they can be used to specifically target the acidic microenvironment of tumor...

Published: 4/23/2021 | Inventor(s): Jie Zheng

Keywords(s): Biocompatible, Biomarkers, Biomaterials, Diagnostics, Healthcare, Imaging, Life Sciences, Materials, Medical, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Imaging