Search Results - life+sciences

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Desensitization and Reduction of Chronic Pain

The University of Texas at Dallas presents a novel class of inhibitors, specificity-derived competitive inhibitor oligonucleotides (SPOT-ONs) that bind to poly(A) binding protein (PABP), and the associated inventive strategy to treat pathological pain. Pathological pain plasticity has been shown to take place in nociceptors, sensory neurons which...

Published: 4/26/2019 | Inventor(s):

Keywords(s): Chemistry, Diagnostics, Healthcare, Life Sciences, Molecular Biology, Therapeutics

Category(s): Research Tools

Novel Aconitase: Targeting Phenotypic Adaptation for Antimicrobial Development

Worldwide, bacterial pathogens pose an alarming public health threat due to their resistance to current antimicrobial drugs. While antibiotics have been widely used to prevent bacterial infections over the last 50-60 years, all major bacterial pathogens now are showing resistance to currently prescribed antibiotics worldwide. Increasing drug resistance...

Published: 4/26/2019 | Inventor(s): Mehmet Candas, Lee Bulla

Keywords(s): Antibiotics, Biomarkers, Life Sciences, Medical, Molecular Biology, Therapeutics

Category(s): Healthcare, Research Tools

Virtual Body-Weight Support via Lower-Limb Exoskeleton

Summary:This is a novel control system for powered lower-limb exoskeletons (or orthoses) that provides body-weight support (BWS) for people who have sustained a stroke and other neurological injury. Patients are provided with BWS during conventional gait retraining to help them produce the coordinated muscle activities needed for walking. Although current...

Published: 5/20/2020 | Inventor(s): Robert Gregg, Ge Lv, Hanqi Zhu

Keywords(s): Biotechnology, Engineering & Physical Sciences, Life Sciences, Medical Devices, Motors, Research Tools, Sensors & Controls, Signal Processing, Therapeutics

Category(s): Electronics, Healthcare, Robotics, Control Strategy, Devices, Mechanical Systems

Amorphous Silicon Carbide Ultramicroelectrode Arrays for Neural Interfaces

The clinical ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response (FBR), which can lead to neuron damage and reduced reliability. Minimizing this tissue response is necessary for the development of implantable interfaces for studying neural...

Published: 4/26/2019 | Inventor(s): Stuart Cogan, Timothy Gardner

Keywords(s): Biocompatible, Electronics, Engineering & Physical Sciences, Implantable, Life Sciences, Materials, Medical, Sensors & Controls, Therapeutics

Category(s): Research Tools, Devices, Healthcare

Neurocase: Peripheral Nerve Electrode for Neural Recording and Stimulation

The ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response, which can lead to neuron damage and reduced reliability of results. Minimizing such tissue responses is necessary to develop implantable interfaces for studying neural activity and even...

Published: 1/5/2022 | Inventor(s): Stuart Cogan, Atefeh Ghazavi, Alexandra Joshi-Imre

Keywords(s): Biocompatible, Biotechnology, Electronics, Engineering & Physical Sciences, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Devices, Research Tools

Powered Prosthetic Leg for Restoring Natural Locomotion and Mobility Across Tasks

Current passive prostheses are used to alleviate the effects of amputation, but they are limited in their ability to completely restore functionality because such mechanisms may only dissipate energy that the user introduces. In the case of above-knee amputees, many passive prosthetic devices aim to mimic normal walking conditions but typically leave...

Published: 5/20/2020 | Inventor(s): Robert Gregg, Toby Elery, Siavash Rezazadeh, Christopher Nesler

Keywords(s): Devices, Electronics, Energy Storage & Battery, Engineering & Physical Sciences, Healthcare, Life Sciences, Mechanical Systems, Medical, Medical Devices, Therapeutics

Category(s): Robotics

Noninvasive & High-Contrast Imaging of Kidney Function Enabled by Renal Clearable Nanofluorophores

The University of Texas at Dallas is seeking companies interested in commercializing a renal-clearable contrast agent that is the first to enable high-resolution, noninvasive, fluorescent imaging of kidney function. Kidney disease affects more than 10% of adults worldwide and the current technologies used to detect and track the progress of renal complications...

Published: 4/26/2019 | Inventor(s): Jie Zheng, Mengxiao Yu

Keywords(s): Biocompatible, Biomarkers, Chemistry, Diagnostics, Healthcare, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools

Category(s): Biomedical, Imaging

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Synthetic Binders of Breast Cancer Stem Cells

In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a root of tumor recurrence and metastasis. Several known...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Luxi Chen, Chao Long

Keywords(s): Assay, Biomarkers, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Polymers, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Method for Measuring Carbon Nanotubes Taken-Up by a Plurality of Living Cells

Carbon nanomaterials (CNMs), including carbon nanotubes (CNTs) and graphene, are undergoing extensive research due to their diverse commercial applications and potential for biomedical uses. The global increase in the production of CNMs and incorporation into consumer products is cause for concern because of the consistent reports that CNMs can be toxic....

Published: 4/26/2019 | Inventor(s): Rockford Draper, Paul Pantano, Ru-Hung Wang, Carole Mikoryak

Keywords(s): Assay, Biotechnology, Carbon Nanomaterials, Carbon Nanotubes, Engineering & Physical Sciences, Healthcare, Imaging, Life Sciences, Materials, Microfluidics, Molecular Biology, Nanotechnology, Processes

Category(s): Research Tools

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