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Multiplexed Chip System for Analysis of Drug Activity in Cell Extracts

This technology uses multielectrode chips with DNA monolayers to analyze drug activity of DNA-damaging cancer treatments to inform therapeutic decisions for personalized medicine. Due to the unpredictability of cancer drugs, it is difficult to identify which therapy will work most effectively for each individual while producing minimal side effects....

Published: 4/26/2019 | Inventor(s): Jason Slinker, Dimithree Kahanda, David Boothman

Keywords(s): Assay, Biomarkers, Cell Lines, Devices, Engineering & Physical Sciences, Materials, Medical, Membrane, Microfluidics, Processes, Therapeutics

Category(s): Electronics, Diagnostics, Healthcare, Research Tools

Desensitization and Reduction of Chronic Pain

The University of Texas at Dallas presents a novel class of inhibitors, specificity-derived competitive inhibitor oligonucleotides (SPOT-ONs) that bind to poly(A) binding protein (PABP), and the associated inventive strategy to treat pathological pain. Pathological pain plasticity has been shown to take place in nociceptors, sensory neurons which...

Published: 4/26/2019 | Inventor(s):

Keywords(s): Chemistry, Diagnostics, Healthcare, Life Sciences, Molecular Biology, Therapeutics

Category(s): Research Tools

Novel Aconitase: Targeting Phenotypic Adaptation for Antimicrobial Development

Worldwide, bacterial pathogens pose an alarming public health threat due to their resistance to current antimicrobial drugs. While antibiotics have been widely used to prevent bacterial infections over the last 50-60 years, all major bacterial pathogens now are showing resistance to currently prescribed antibiotics worldwide. Increasing drug resistance...

Published: 4/26/2019 | Inventor(s): Mehmet Candas, Lee Bulla

Keywords(s): Antibiotics, Biomarkers, Life Sciences, Medical, Molecular Biology, Therapeutics

Category(s): Healthcare, Research Tools

Amorphous Silicon Carbide Ultramicroelectrode Arrays for Neural Interfaces

The clinical ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response (FBR), which can lead to neuron damage and reduced reliability. Minimizing this tissue response is necessary for the development of implantable interfaces for studying neural...

Published: 4/26/2019 | Inventor(s): Stuart Cogan, Timothy Gardner

Keywords(s): Biocompatible, Electronics, Engineering & Physical Sciences, Implantable, Life Sciences, Materials, Medical, Sensors & Controls, Therapeutics

Category(s): Research Tools, Devices, Healthcare

Neurocase: Peripheral Nerve Electrode for Neural Recording and Stimulation

The ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response, which can lead to neuron damage and reduced reliability of results. Minimizing such tissue responses is necessary to develop implantable interfaces for studying neural activity and even...

Published: 1/5/2022 | Inventor(s): Stuart Cogan, Atefeh Ghazavi, Alexandra Joshi-Imre

Keywords(s): Biocompatible, Biotechnology, Electronics, Engineering & Physical Sciences, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Devices, Research Tools

Method for Measuring Carbon Nanotubes Taken-Up by a Plurality of Living Cells

Carbon nanomaterials (CNMs), including carbon nanotubes (CNTs) and graphene, are undergoing extensive research due to their diverse commercial applications and potential for biomedical uses. The global increase in the production of CNMs and incorporation into consumer products is cause for concern because of the consistent reports that CNMs can be toxic....

Published: 4/26/2019 | Inventor(s): Rockford Draper, Paul Pantano, Ru-Hung Wang, Carole Mikoryak

Keywords(s): Assay, Biotechnology, Carbon Nanomaterials, Carbon Nanotubes, Engineering & Physical Sciences, Healthcare, Imaging, Life Sciences, Materials, Microfluidics, Molecular Biology, Nanotechnology, Processes

Category(s): Research Tools