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Transient Optical Opening of the Blood-Brain Barrier by Laser Excitation of Plasmonic Nanoparticles

The blood-brain barrier (BBB) poses a low permeability to most drugs and poses a significant challenge to effective treatment of brain diseases. The BBB restricts the delivery of most drug molecules into the brain by tight junctions (TJs) that seal gaps between adjacent endothelial cells, displaying low permeability and high electrical resistance. Herein,...

Published: 4/26/2019 | Inventor(s): Zhenpeng Qin, Xiaoqing Li, Xiuying Li, Shashank Sirsi, Heather Hayenga, Edward Pan

Keywords(s): Biomarkers, Diagnostics, Drug Delivery, Engineering & Physical Sciences, Imaging, Materials, Medical, Research Tools, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Synthetic Binders of Breast Cancer Stem Cells

In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a root of tumor recurrence and metastasis. Several known...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Luxi Chen, Chao Long

Keywords(s): Assay, Biomarkers, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Polymers, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Efficient & Broadband Even-Order Harmonic Multiplication in Standard CMOS

A novel technique to realize highly-efficient passive multipliers in a standard CMOS process is demonstrated to efficiently generate even-order harmonics while simultaneously suppressing odd-order harmonics over broad-bandwidths. This is achieved by improving the cutoff frequency (fT) well beyond a THz. The higher fT combined with proposed nonlinearity...

Published: 4/26/2019 | Inventor(s): Kenneth O, Zeshan Ahmad

Keywords(s): Devices, Electronics, Engineering & Physical Sciences, Imaging, Optics & Photonics, Semiconductor, MEMS & Nanotechnology, Signal Processing, Wireless

Category(s): Communications

Method for Measuring Carbon Nanotubes Taken-Up by a Plurality of Living Cells

Carbon nanomaterials (CNMs), including carbon nanotubes (CNTs) and graphene, are undergoing extensive research due to their diverse commercial applications and potential for biomedical uses. The global increase in the production of CNMs and incorporation into consumer products is cause for concern because of the consistent reports that CNMs can be toxic....

Published: 4/26/2019 | Inventor(s): Rockford Draper, Paul Pantano, Ru-Hung Wang, Carole Mikoryak

Keywords(s): Assay, Biotechnology, Carbon Nanomaterials, Carbon Nanotubes, Engineering & Physical Sciences, Healthcare, Imaging, Life Sciences, Materials, Microfluidics, Molecular Biology, Nanotechnology, Processes

Category(s): Research Tools

Novel Class of pH Responsive and Renal Clearable Tumor Imaging Agents

Non-Confidential Description:The technology is a novel class of pH responsive luminescent gold nanoparticles that are renal clearable and that selectively bind to cells in an acidic environment such as tumor cells. An advantage of these novel pH responsive nanoparticles is that they can be used to specifically target the acidic microenvironment of tumor...

Published: 4/23/2021 | Inventor(s): Jie Zheng

Keywords(s): Biocompatible, Biomarkers, Biomaterials, Diagnostics, Healthcare, Imaging, Life Sciences, Materials, Medical, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Imaging