Search Results - drug+delivery

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Transient Optical Opening of the Blood-Brain Barrier by Laser Excitation of Plasmonic Nanoparticles

The blood-brain barrier (BBB) poses a low permeability to most drugs and poses a significant challenge to effective treatment of brain diseases. The BBB restricts the delivery of most drug molecules into the brain by tight junctions (TJs) that seal gaps between adjacent endothelial cells, displaying low permeability and high electrical resistance. Herein,...

Published: 4/26/2019 | Inventor(s): Zhenpeng Qin, Xiaoqing Li, Xiuying Li, Shashank Sirsi, Heather Hayenga, Edward Pan

Keywords(s): Biomarkers, Diagnostics, Drug Delivery, Engineering & Physical Sciences, Imaging, Materials, Medical, Research Tools, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Multifunctional Ionic liquids for Surface Modification of Dental Implants

Titanium dental implants are known for their high success rates and adequate osseointegration in vivo. However, with an increasing number of implants used, higher incidence of failures has been reported. These failures have been associated with microbial colonization, peri-implant inflammation, corrosion, implant design, overload, as well as a combination...

Published: 4/26/2019 | Inventor(s): Danieli Rodrigues, Izabelle De Mello Gindri

Keywords(s): Antibodies, Biocompatible, Biomaterials, Coatings, Drug Delivery, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Dental

Novel Nitric Oxide Releasing Surgical Sutures, Bandages and Fabrics

Non-Confidential DescriptionThe technology is novel nitric oxide (NO) releasing acrylonitrile-based copolymer and terpolymer fibers that can be used as surgical sutures or non-woven bandages and fabrics that enhance wound healing. These copolymers have a higher NO loading capacity per gram than other known NO releasing acrylonitrile polymers. In addition,...

Published: 4/26/2019 | Inventor(s): Kenneth Balkus, Alysia Lowe, Dennis Smith, Wenjin Deng

Keywords(s): Biocompatible, Drug Delivery, Healthcare, Life Sciences, Materials, Medical, Medical Devices, Polymers, Textiles, Therapeutics

Category(s): Healthcare

Biscrolling Nanopowders and Carbon Nanotube Sheets into Fibers, Yarns and Textiles

Non-Confidential Description:The technology is the first known method to spin biscrolled fibers/yarns from nanopowder materials using carbon nanotube (CNT) sheets as the host. Nanopowder materials (nanoparticles, nanofibers) are loaded onto the CNT sheets to form bi-layered sheets, which are then scrolled into fibers. A key advantage of this technology...

Published: 4/26/2019 | Inventor(s): Ray Baughman, Shaoli Fang, Marcio Lima, Raquel Robles, Xavier Lepro-Chavez, Mohammad Haque, Anvar Zakhidov, Chihye Lewis Azad, Javier Carretero-Gonzalez, Elizabet Castillo-Martinez, Carter Haines, David Novitski, Mikhail Kozlov

Keywords(s): Chemistry, Coatings, Drug Delivery, Electronics, Energy Storage & Battery, Engineering & Physical Sciences, Healthcare, Processes, Semiconductor, MEMS & Nanotechnology, Textiles

Category(s): Materials, Nanotechnology

Electrolyte-Free Charge Injection Tuning of Carbon Nanotube Sheets – Offering Novel Supercapacitor Technology

This invention utilizes bulk material property modification via hole or electron injection into conducting and porous materials including but not limited to carbon nanotubes. Bulk carbon nanotube (CNT) assemblies (sheets, rods, etc) can be charged electrochemically in an electrolyte bath. After the CNT sheet is charged (positively or negatively) in...

Published: 4/26/2019 | Inventor(s): Dong-Seok Suh, Ray Baughman, Anvar Zakhidov

Keywords(s): Carbon Nanotubes, Chemistry, Devices, Drug Delivery, Energy Storage & Battery, Engineering & Physical Sciences, Nanotechnology, Research Tools, Textiles

Category(s): Energy, Materials, Electronics

A Method of Storage and Controlled Delivery of Nitric Oxide

Invention:The invention is unique Titanium dioxide nanotubes decorated with NO releasing groups to store and deliver NO using photochemical methods in both external and internal medical treatments. It provides a method of storing NO that can be delivered to targeted spaces and a controlled photodynamic activation process that eliminates any potential...

Published: 10/26/2022 | Inventor(s): Kenneth Balkus, Chalita Ratanatawanate

Keywords(s): Biocompatible, Chemistry, Drug Delivery, Engineering & Physical Sciences, Materials, Medical Devices, Textiles, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

A Method of Nitric Oxide Delivery for Healing and Organ Preservation

Invention:The invention is a medical device, more specifically a bandage, which releases Nitric Oxide to help heal wounds, improve blood circulation and preserve organs being stored for transplant.Nitric Oxide opens blood vessels and keep them relaxed, two of the key factors that help blood flow. Secondly this device inhibits thrombosis thereby preserving...

Published: 10/26/2022 | Inventor(s): Kenneth Balkus, Harvey Liu, Chalita Ratanatawanate

Keywords(s): Biocompatible, Chemistry, Devices, Drug Delivery, Engineering & Physical Sciences, Healthcare, Medical, Medical Devices, Therapeutics

Category(s): Materials, Biomedical