Search Results - biomedical

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Transient Optical Opening of the Blood-Brain Barrier by Laser Excitation of Plasmonic Nanoparticles

The blood-brain barrier (BBB) poses a low permeability to most drugs and poses a significant challenge to effective treatment of brain diseases. The BBB restricts the delivery of most drug molecules into the brain by tight junctions (TJs) that seal gaps between adjacent endothelial cells, displaying low permeability and high electrical resistance. Herein,...

Published: 4/26/2019 | Inventor(s): Zhenpeng Qin, Xiaoqing Li, Xiuying Li, Shashank Sirsi, Heather Hayenga, Edward Pan

Keywords(s): Biomarkers, Diagnostics, Drug Delivery, Engineering & Physical Sciences, Imaging, Materials, Medical, Research Tools, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

Neurocase: Peripheral Nerve Electrode for Neural Recording and Stimulation

The ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response, which can lead to neuron damage and reduced reliability of results. Minimizing such tissue responses is necessary to develop implantable interfaces for studying neural activity and even...

Published: 1/5/2022 | Inventor(s): Stuart Cogan, Atefeh Ghazavi, Alexandra Joshi-Imre

Keywords(s): Biocompatible, Biotechnology, Electronics, Engineering & Physical Sciences, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Devices, Research Tools

Noninvasive & High-Contrast Imaging of Kidney Function Enabled by Renal Clearable Nanofluorophores

The University of Texas at Dallas is seeking companies interested in commercializing a renal-clearable contrast agent that is the first to enable high-resolution, noninvasive, fluorescent imaging of kidney function. Kidney disease affects more than 10% of adults worldwide and the current technologies used to detect and track the progress of renal complications...

Published: 4/26/2019 | Inventor(s): Jie Zheng, Mengxiao Yu

Keywords(s): Biocompatible, Biomarkers, Chemistry, Diagnostics, Healthcare, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools

Category(s): Biomedical, Imaging

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Synthetic Binders of Breast Cancer Stem Cells

In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a root of tumor recurrence and metastasis. Several known...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Luxi Chen, Chao Long

Keywords(s): Assay, Biomarkers, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Polymers, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Enhancing Plasticity and Recovery Following Spinal Cord Injury

Spinal cord injury (SCI) can lead to a wide range of functional impairments that reduce the independence and quality of life for millions worldwide. Intense rehabilitation therapy is the most consistently effective therapy for SCI patients, but serious impairments may persist even after years of treatment.While the impairments that result from SCI are...

Published: 4/26/2019 | Inventor(s): Robert Rennaker, Michael Kilgard, Seth Hays, Patrick Ganzer

Keywords(s): Electronics, Healthcare, Implantable, Life Sciences, Medical, Medical Devices, Therapeutics

Category(s): Biomedical

Improved Dental Abutment Geometries for Cement-Retained Crowns

According to the American Academy of Implant Dentistry, over 500,000 dental implants are performed per year in the United States. Despite being such a common procedure, peri-implant disease has been found to affect as much as 48% of implants according to the American Academy of Periodontology. Inefficiencies of commercial dental implant systems have...

Published: 4/26/2019 | Inventor(s): Lucas Rodriguez, Danieli Rodrigues, Juliana Saba, Chandur Wadhwani

Keywords(s): Biocompatible, Biomaterials, Devices, Healthcare, Implantable, Life Sciences, Mechanical Systems, Medical, Medical Devices

Category(s): Biomedical, Dental

Multifunctional Ionic liquids for Surface Modification of Dental Implants

Titanium dental implants are known for their high success rates and adequate osseointegration in vivo. However, with an increasing number of implants used, higher incidence of failures has been reported. These failures have been associated with microbial colonization, peri-implant inflammation, corrosion, implant design, overload, as well as a combination...

Published: 4/26/2019 | Inventor(s): Danieli Rodrigues, Izabelle De Mello Gindri

Keywords(s): Antibodies, Biocompatible, Biomaterials, Coatings, Drug Delivery, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Dental

Unified Lower-Limb Prosthetic Control Strategy

Non-Confidential Description: This technology defines a novel control strategy for a powered prosthetic leg that unifies the entire gait cycle, eliminating the need to switch between controllers during different periods of gait. Current control methods divide the gait cycle into several sequential periods with independent controllers, resulting...

Published: 5/20/2020 | Inventor(s): Robert Gregg, David Quintero, Anne Martin

Keywords(s): Biotechnology, Devices, Electronics, Engineering & Physical Sciences, Healthcare, Life Sciences, Mechanical Systems, Motors, Sensors & Controls, Therapeutics

Category(s): Biomedical, Control Strategy, Robotics

Novel Class of pH Responsive and Renal Clearable Tumor Imaging Agents

Non-Confidential Description:The technology is a novel class of pH responsive luminescent gold nanoparticles that are renal clearable and that selectively bind to cells in an acidic environment such as tumor cells. An advantage of these novel pH responsive nanoparticles is that they can be used to specifically target the acidic microenvironment of tumor...

Published: 4/23/2021 | Inventor(s): Jie Zheng

Keywords(s): Biocompatible, Biomarkers, Biomaterials, Diagnostics, Healthcare, Imaging, Life Sciences, Materials, Medical, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Imaging

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