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Hardware and Software System for At-Home Stereognosis Training

Sensory loss of the hand (including impaired proprioception, stereognosis, and tactile sensation) is common after peripheral nerve damage, stroke, spinal cord injury, multiple sclerosis (MS), and other neurological conditions. While sensory retraining therapy has shown some benefits, there is no established method to restore tactile sensation following...

Published: 1/5/2022 | Inventor(s): Michael Kilgard

Keywords(s): Devices, Engineering & Physical Sciences, Internet of Things (IoT), Medical, Research Tools, Software, Therapeutics, Wireless

Category(s): Diagnostics, Healthcare, Medical Devices

Multiplexed Chip System for Analysis of Drug Activity in Cell Extracts

This technology uses multielectrode chips with DNA monolayers to analyze drug activity of DNA-damaging cancer treatments to inform therapeutic decisions for personalized medicine. Due to the unpredictability of cancer drugs, it is difficult to identify which therapy will work most effectively for each individual while producing minimal side effects....

Published: 4/26/2019 | Inventor(s): Jason Slinker, Dimithree Kahanda, David Boothman

Keywords(s): Assay, Biomarkers, Cell Lines, Devices, Engineering & Physical Sciences, Materials, Medical, Membrane, Microfluidics, Processes, Therapeutics

Category(s): Electronics, Diagnostics, Healthcare, Research Tools

Transient Optical Opening of the Blood-Brain Barrier by Laser Excitation of Plasmonic Nanoparticles

The blood-brain barrier (BBB) poses a low permeability to most drugs and poses a significant challenge to effective treatment of brain diseases. The BBB restricts the delivery of most drug molecules into the brain by tight junctions (TJs) that seal gaps between adjacent endothelial cells, displaying low permeability and high electrical resistance. Herein,...

Published: 4/26/2019 | Inventor(s): Zhenpeng Qin, Xiaoqing Li, Xiuying Li, Shashank Sirsi, Heather Hayenga, Edward Pan

Keywords(s): Biomarkers, Diagnostics, Drug Delivery, Engineering & Physical Sciences, Imaging, Materials, Medical, Research Tools, Therapeutics

Category(s): Biomedical, Nanotechnology, Healthcare

Novel Aconitase: Targeting Phenotypic Adaptation for Antimicrobial Development

Worldwide, bacterial pathogens pose an alarming public health threat due to their resistance to current antimicrobial drugs. While antibiotics have been widely used to prevent bacterial infections over the last 50-60 years, all major bacterial pathogens now are showing resistance to currently prescribed antibiotics worldwide. Increasing drug resistance...

Published: 4/26/2019 | Inventor(s): Mehmet Candas, Lee Bulla

Keywords(s): Antibiotics, Biomarkers, Life Sciences, Medical, Molecular Biology, Therapeutics

Category(s): Healthcare, Research Tools

Amorphous Silicon Carbide Ultramicroelectrode Arrays for Neural Interfaces

The clinical ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response (FBR), which can lead to neuron damage and reduced reliability. Minimizing this tissue response is necessary for the development of implantable interfaces for studying neural...

Published: 4/26/2019 | Inventor(s): Stuart Cogan, Timothy Gardner

Keywords(s): Biocompatible, Electronics, Engineering & Physical Sciences, Implantable, Life Sciences, Materials, Medical, Sensors & Controls, Therapeutics

Category(s): Research Tools, Devices, Healthcare

Neurocase: Peripheral Nerve Electrode for Neural Recording and Stimulation

The ability to record and stimulate neural activity with implanted microelectrode arrays has been limited by the problems of insertion trauma and foreign body response, which can lead to neuron damage and reduced reliability of results. Minimizing such tissue responses is necessary to develop implantable interfaces for studying neural activity and even...

Published: 1/5/2022 | Inventor(s): Stuart Cogan, Atefeh Ghazavi, Alexandra Joshi-Imre

Keywords(s): Biocompatible, Biotechnology, Electronics, Engineering & Physical Sciences, Healthcare, Implantable, Life Sciences, Materials, Medical, Medical Devices, Therapeutics

Category(s): Biomedical, Devices, Research Tools

Powered Prosthetic Leg for Restoring Natural Locomotion and Mobility Across Tasks

Current passive prostheses are used to alleviate the effects of amputation, but they are limited in their ability to completely restore functionality because such mechanisms may only dissipate energy that the user introduces. In the case of above-knee amputees, many passive prosthetic devices aim to mimic normal walking conditions but typically leave...

Published: 5/20/2020 | Inventor(s): Robert Gregg, Toby Elery, Siavash Rezazadeh, Christopher Nesler

Keywords(s): Devices, Electronics, Energy Storage & Battery, Engineering & Physical Sciences, Healthcare, Life Sciences, Mechanical Systems, Medical, Medical Devices, Therapeutics

Category(s): Robotics

Noninvasive & High-Contrast Imaging of Kidney Function Enabled by Renal Clearable Nanofluorophores

The University of Texas at Dallas is seeking companies interested in commercializing a renal-clearable contrast agent that is the first to enable high-resolution, noninvasive, fluorescent imaging of kidney function. Kidney disease affects more than 10% of adults worldwide and the current technologies used to detect and track the progress of renal complications...

Published: 4/26/2019 | Inventor(s): Jie Zheng, Mengxiao Yu

Keywords(s): Biocompatible, Biomarkers, Chemistry, Diagnostics, Healthcare, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools

Category(s): Biomedical, Imaging

Small Molecule Inhibitor of Forkhead Box Protein C2 (FOXC2): Therapeutic Candidate and Diagnostic Tool for Metastatic Cancers

The transcription factor Forkhead Box Protein C2 (FOXC2) is known to be necessary to initiate and maintain the epithelial-mesenchymal transition (EMT), which has been a hot target for therapeutic intervention against cancers. The overexpression of FOXC2 bestows cancer cells with metastatic and cancer stem cell (CSC)‐like phenotypes, i.e., higher motility,...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Maria Castaneda

Keywords(s): Assay, Biocompatible, Biomarkers, Chemistry, Drug Delivery, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Nanotechnology, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

Synthetic Binders of Breast Cancer Stem Cells

In recent decades, abundant research data has indicated the existence of cancer stem cells (CSCs), which represent a small, but significant, population among all cells within tumor tissues. These CSCs are mostly responsible for resistance to chemotherapy and radiation therapy, thereby becoming a root of tumor recurrence and metastasis. Several known...

Published: 4/26/2019 | Inventor(s): Jiyong Lee, Luxi Chen, Chao Long

Keywords(s): Assay, Biomarkers, Healthcare, Imaging, Life Sciences, Medical, Molecular Biology, Polymers, Research Tools, Therapeutics

Category(s): Biomedical, Diagnostics

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