Novel Nitric Oxide Releasing Surgical Sutures, Bandages and Fabrics


Non-Confidential Description

The technology is novel nitric oxide (NO) releasing acrylonitrile-based copolymer and terpolymer fibers that can be used as surgical sutures or non-woven bandages and fabrics that enhance wound healing. These copolymers have a higher NO loading capacity per gram than other known NO releasing acrylonitrile polymers. In addition, the fibers are coated with biodegradable polymers that allow for the timed, slow release of NO when the suture, bandage or fabric is in contact with the wound. These fibers have a long shelf life and when used in wound closure applications have the potential to deliver therapeutic NO specifically to the wound area, thereby promoting wound healing. Animal studies have been conducted which confirm the efficacy of these bandages for enhanced wound healing.


Implantable medical devices (stents, pacemakers, wire-guides, sutures etc.) that are in constant contact with a patient’s vascular system have been known to cause thrombosis and platelet aggregation both internally and on the device itself, resulting in clinical complications such as restenosis,  infections and/ or reduction in device performance.


NO prevents platelet aggregation, promotes vasodilation, has antimicrobial properties and has been demonstrated to enhance wound healing. Using medical devices that release NO specifically to the wound over time will help prevent infections and promote wound healing. These NO releasing sutures can be used to both close surgical incisions or wounds and enhance healing.  According to Freedonia, the wound management market is estimated to increase at 5.3% annually to 39.3 billion in 2016.  The market for Wound closures and bandages is projected to reach 15.2 billion and 10 billion respectively, in 2016.


Potential Benefits

·         Higher Efficiency

Higher NO loading capacity; efficient and timed release of NO

·         Customizable

Fiber diameter can be customized for different applications


 Potential Applications

·         Wound care & management

Surgical sutures and bandages for wound closure, treatment and chronic wound management.

·         Safe surgical implants


Coating of surgical implants with the co-polymer will mitigate the risk of thrombosis and restenosis

 IP Status

United States patent 9,017,653 issued on April 28, 2015.


Dr. Kenneth Balkus  

Alysia Lowe

Dr. Dennis Smith

Dr. Wenjin Deng


ID Number: MP –11-038


Licensing Opportunity: This technology is available for exclusive or non-exclusive licensing.




Patent Information:
For Information, Contact:
OTC Licensing
Kenneth Balkus
Alysia Lowe
Dennis Smith
Wenjin Deng
Drug Delivery
Life Sciences
Medical Devices
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